SPXV launched in September 2015 as part of the ex-sector suite from ProShares, which seek to represent the US large-cap space without exposure to a specific sector. The fund starts with the S&P 500 index constituents. From this selection universe, companies are classified by sector according to GICS and those under health care are excluded from the portfolio. Selected securities are market-cap-weighted and rebalanced quarterly. SPXN might be used either speculatively when you want to bet on the underperformance of the health care sector, or complementary when you already have large positions in the health care industry, and are looking to diversify.